Kushandiswa kweOrdinary Zinc Oxid muAnti-diarrhea yenguruve

III. Zvinetso zvemanyoka munguruve dzakarumurwa uye kukosha kwekiriniki kwezinc oxide

Kurumurwa chiitiko chikuru chinoshungurudza muhupenyu hwenguruve. Matambudziko akadai seasina kusimba emudumbu barriers basa, kusakwana kwekuvanzika kwema enzymes ekugaya, uye kusaenzana kwemaruva kunowanzo tungamira kune post-weaning diarrhea (PWD), iyo inotyisidzira zvakanyanya kukura kwekuita uye kubereka mabhenefiti enguruve. Kubva zvakajairikazinc oxideyakawanikwa iine mhedzisiro yakakura yekurwisa manyoka muma1980s, yave "chiyero chegoridhe" cheindasitiri yezvipfuyo pasi rose kubata nePWD. Zvidzidzo zvakaratidza kuti kuwedzera 2500-3000 mg/kgzinc oxideinogona kuderedza chiyero chemanyoka ne40% -60%, ichiwedzera kuwedzera kwezuva nezuva kuwedzera ne10% -15%. Kukosha kwayo kukuru kuri mukukurumidza kudzikamisa nharaunda yematumbo kuburikidza nemaitiro akawanda, ichipa yakakosha shanduko yekudzivirira kwenguruve.

IV.The mechanism of action ofzinc oxidekurwisa manyoka

1)Kusimbisa intestinal physical barriers

Zinc oxideinokurudzira kuwanda kwemasero emudumbu epithelial, zvakanyanya kuwedzera chiyero che intestinal villus kureba kusvika ku crypt deep, inovandudza nzvimbo yepamusoro yekutora kudya, uye panguva imwe chete inokwidziridza kutaura kwemapuroteni akaoma (Occludin, ZO-1), inoderedza intestinal mucosal permeability, uye inodzivisa pathogen invasion. Inodzivirira intestinal mucosal barrier function, inovandudza antibacterial kugona kwenguruve, uye inoderedza manyoka.

Fig 2Migumisiro yezviyero zvakasiyana zvezinc oxidepamusoro pe intestinal morphology yenguruve

Fig 3Migumisiro yezviyero zvakasiyana zvezinc oxidepa intestinal tight junction mapuroteni munguruve

2)Kugadzirisa intestinal microbial balance

Zinc oxideinogadzira hydrogen peroxide mahara radicals mumatumbo, inova chinhu chakakosha mukuita kweantibacterialzinc oxide. High-dosezinc oxideinodzivisa zvakananga kupararira kwehutachiona hwehutachiona hwakadai seEscherichia coli uye Salmonella nekusunungura reactive oxygen species (ROS), apo ichikurudzira kuumbwa kwebhakitiriya inobatsira seLactobacillus.

Fig 4Migumisiro yezvokudyazinc oxidepamusoro pececal microorganisms munguruve

3) High zinc inosimudzira kukura kwenguruve

Kushungurudzika kwekurumurwa kunokonzera kudzikira kwe30% mukudya kwekudya, uye kugayiwa kwezvokudya munguruve dzakarumurwa kunowedzera kudzikira padzinenge dzichiita manyoka. Zvidzidzo zvakaratidzakutikuwedzera madosi makuru ezinc oxidekune kudya kunogona kuwedzera zinc level muropa, wedzera kudzora kuburitswa kwehuropi gut peptides uye nzara mahomoni,uyekurudzira nguruve kuti dzidye. Panguva imwe, kuwedzera kwezinc content muropaanogonazvinobudirira kukurudzira synthesis uye activation of digestive enzymes, kunatsiridza digestibility yezvinovaka muviri,uyewedzera huremu hwezuva nezuva hwenguruve.

Fig 5Mhedzisiro ye zinc oxide pakukura kwenguruve dzakarumurwa

IV. Scientific Application Plan uye Precautions

1. Yakarurama dosage uye kushandiswa kutenderera

Kunyangwe zvichitaurwa kuti yakakwira zinc (1600-2500 mg/kgzinc oxide) chikafu chinogona kushandiswa chete mu”mavhiki maviri ekutanga mushure mekurumurwa”, mapurazi akawanda enguruve anowedzera kushandiswa kwepamusoro zinc feed kwemavhiki 2-8. Panguva ino, mamwe mapurazi enguruve achasangana”high zinc side effects”, ayo anowanzo kuratidzwa sebvudzi gobvu uye refu uye ganda rakasviba.

2. Sarudzazinc oxidenekugadzikana kwepamusoro kuvandudza chigadzirwa mhedzisiro

Iyo bioavailability yezinc oxideinogadzirwa nekunyorova nzira yakanyanya kukwira kupfuura iyo yezinc oxideinogadzirwa nenzira yakananga. Naizvozvo, pakusarudzazinc oxidezvigadzirwa, maitiro ayo ekugadzira anofanirwawo kutariswa.

5. Indasitiri Trends uye Alternative Technology Outlook

Kunyangwe hazvo EU yakaganhurira huwandu hwezinc yakawedzerwa ku150 mg/kg, tsika dzemumba dzinoratidza kuti kutsiva zvachose zinc yakakwira kuchiri kutarisana nemabhodhoro ehunyanzvi. Dzimwe nzira dzazvino dzakadai se nanozinc oxide(300 mg / kg) uye basic zinc chloride (1200 mg / kg) inogona kuderedza muyero, asi mutengo wavo wakakwira, kugadzikana kwemaitiro hakuna kukwana, uye kuchengetedzwa kwenguva refu kuchiri kudikanwa kuongororwa. Naizvozvo,zvakajairikazinc oxideichiri sarudzo yakanakisa yemapurazi madiki uye epakati nepakati kuenzanisa mutengo nemhedzisiro.

Zvakajairikazinc oxide

Sustar chizvarwa chekutangazinc oxide

Kuchena kwakakwirira + kwepamusoro + mutengo wakaderera = mabhenefiti matatu mune imwe

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